Orthopedics field
Nano‑Material Custom Synthesis Service | ACS Nano Biomimetic Periosteum | Dual‑Layer Micro/Nanofibers + Self‑Adhesive Hydrogel
Journal Source:
ACS Nano (ACS Publications)
Title:
Biomimetic Self‑Adhesive Artificial Periosteum with Micro/Nanofibrous Structure Accelerates Bone Reconstruction via Synergistic Osteogenesis and Angiogenesis
Research Concept:
This work designs a biomimetic bilayer artificial periosteum (CP‑HP). The outer layer is an aligned polycaprolactone‑chitosan (PCL‑CS) micro/nanofibrous membrane, and the inner layer is an adhesive hydroxyapatite‑polydopamine‑polyacrylamide (HA‑PDA‑PAM) hydrogel. Mimicking the fibrous layer of native periosteum, the outer layer provides topological guidance and a mechanical barrier. The inner layer recapitulates the osteogenic layer to offer a mineralized microenvironment and tissue adhesion. Through dual biomimicry of structure and function, the two layers work synergistically to boost coupled osteogenesis and angiogenesis.
Material Development:
(1) Materials: Outer layer — hierarchically aligned fibrous membrane self‑assembled from electrospun PCL microfibers and CS nanofibers; Inner layer — PDA‑PAM hydrogel incorporated with nano‑hydroxyapatite (HA).
(2) Functions: The outer layer affords contact guidance, immunomodulation and barrier properties to facilitate vascularization. The inner layer achieves wet‑state tissue adhesion via PDA, while HA constructs an osteoinductive microenvironment to stabilize the implant‑tissue interface and support osteogenic differentiation.
Highlights:
- A bilayer biomimetic design with coupled “structure‑function” effects is proposed, which reproduces both the hierarchical architecture of native periosteum and the coupled osteogenic‑angiogenic mechanism.
- An alkaline system is adopted to trigger CS self‑assembly for nanofiber formation, which builds a hierarchical structure together with PCL microfibers to improve mechanical performance and biological activity.
- PDA is introduced to endow hydrogel with self‑adhesion, enabling stable attachment onto defects without extra fixation. Incorporated HA further enhances osteoinductivity.
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