Super-multiple nucleic acid detection chips and equipment
Fully automatic integrated ultra-multiple nucleic acid detection chip and equipment based on channel-digital microfluidic platform is an efficient, sensitive and quantitative detection method for nucleic acid amplification and fluorescence detection using microfluidic technology, which can be used for rapid detection of infectious agents such as SARS-CoV-2. Automated nucleic acid detection platform based on digital microfluidic and optimized Cas12a system: an automated nucleic acid detection platform based on digital microfluidic and optimized Cas12a system can realize rapid and accurate detection of influenza virus and SARS-CoV-2. The platform uses digital microfluidic technology to achieve microupgrade control and effective mixing of reaction droplets, shortening the detection time and reducing the risk of aerosol contamination. The platform also optimized the probes in the RPA-Cas12a system, increasing the intensity of the fluorescence signal. The platform has high sensitivity, specificity, speed (30 min), automation and multiplexing, and can complete the whole process from amplification to identification on the chip. The platform was also used to detect nucleic acids in influenza patients and COVID-19 patients, and the results were consistent with qPCR. Automated nucleic acid detection platform based on centrifugal microfluidic and CRISPR-Cas13a system: Automatic nucleic acid detection platform based on centrifugal microfluidic and CRISPR-Cas13a system can realize the simultaneous detection of various infectious disease pathogens such as SARS-CoV-2, dengue virus, and Zika virus. The platform uses centrifugal forces to drive the droplets moving on the chip and enables droplet dispensing, merging, and mixing through the valve. The platform also enables nucleic acid amplification and fluorescence signal conversion using the CRISPR-Cas13a system, with high sensitivity and specificity. The platform can perform multiple nucleic acid tests in 35 min without complex instruments and professionals. Automated nucleic acid detection platform based on channel microfluidic and LAMP technology: Automatic nucleic acid detection platform based on channel microfluidic and LAMP technology can realize rapid, sensitive and quantitative detection of various infectious diseases such as SARS-CoV-2, Ebola virus and dengue virus. The platform utilizes channel microfluidic technology to enable the integration and automation of steps including sample processing, nucleic acid extraction, LAMP reactions, and fluorescence detection without manual manipulation. The platform also enables homoic nucleic acid amplification using LAMP technology and quantitative analysis by fluorescence signal feedback. This platform can perform multiple nucleic acid detection in 30 min with high sensitivity and specificity.
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