Construction of biomedical polymeric nanomotor and its application in disease treatment
Biomedical polymer nanomotor is a kind of micro-nano scale self-driving device built using biomolecules or polymer materials. It can transform external energy (such as light, magnetism, chemistry, etc.) into its own movement, and realize the load, delivery and release of drugs, genes, cells and other biological drugs. Such nanomotor has good biocompatibility, degradability, programmable and responsive, providing new technical means for precision medicine. At present, the research on the application of biomedical polymer nanomotors in disease treatment mainly focuses on cancer, thrombosis, ophthalmic diseases, orthopedic diseases, gastrointestinal diseases and cardiovascular diseases.for instance: A DNA nano-robot based on supramolecular self-assembly can deliver thrombin to the tumor site and realize tumor embolization therapy; A nanomotor with a graded pore structure can simultaneously load drugs of different sizes and functions, and realize cancer chemotherapy / photothermal combination therapy; A platelet-modified mesoporous / macroporous silica / platinum nanomotor that targets thrombolysis and anticoagulants to the thrombus site for treatment; A nanomotor based on polyethylene glycol-polypropylene ester copolymer that can deliver antioxidants to the eye to treat ophthalmic diseases caused by oxidative stress; A PLA-polyethylene glycol copolymer-based nanomotor that can deliver antimicrobial peptides to the stomach to treat Helicobacter pylori infection; A nanomotor based on PEG-polycaprolactone copolymer that can deliver anti-myocardial ischemic drugs to cardiac tissue for the treatment of myocardial infarction.
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