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Biohybrid minichorbots refers to micrometer or nanoscale artificial robots that use biological cells or microorganisms as power sources or functional elements, and can achieve specific functions in or outside the organism, such as detection, imaging, delivery, diagnosis, treatment and so on. These robots can use the autonomous movement, perception, and adaptation capabilities of biological cells or microorganisms to achieve targeted delivery of specific targets within the organism. These robots have the advantages of high efficiency, precision and safety, and can be used in a variety of applications in the field of anti-tumor therapy. Case of targeted delivery of biohybrid microrobots: E. coli (E. coli) can achieve magnetron motion and targeted delivery in life. The E. coli cell surface was modified as nanocarriers with pH responsiveness and tumor targeting, and anticancer drugs or immunostimulants were loaded inside their interior to form a biohybrid microbot. The robot can enter the intestine by oral administration and release drugs or immunostimulants stimulated by low pH in the tumor microenvironment, achieving chemical killing or immune activation of tumor cells. Sperm cell (sperm cell) -based biohybrid microrobot can achieve light-controlled movement and targeted delivery in life. Sperm cells are wrapped in a polymer layer with photosensitivity and drug loading capacity to form a biohybrid microrobot. The robot can control the direction and speed of its movement by the external laser, and release the drug after reaching the target position, realizing the treatment of cervical cancer cells. Biohybrid microrobots based on red blood cells (erythrocyte) can realize sound-controlled movement and targeted delivery in live bodies. The red blood cell surface is modified into nanocarriers with acoustic response and tumor targeting, and the anticancer drugs are loaded in its interior to form a biological hybrid microrobot. The robot can control the direction and speed of its movement through the external ultrasound wave, and release the drug after reaching the target position, realizing the treatment of liver cancer cells.